![]() Various physiological functions depend on CSF transportation like regeneration of the brain during sleep, etc. It delivers a site for the interaction between the brain and the immune system and a drainage way so that the water molecules from the brain are cleared. The CSF circulation enters from the subarachnoid space into the Virchow Robin space. The steady exchange of bidirectional fluid yields a flow rate that boosts the choroidal CSF production rate. ![]() Speedy carrier of brain water and CSF homeostasis occurs through astrocytes, aquaporin, and other membranes. Its circulation does not constitute a directed flow only, but it is a flow with periodic variations that is filled all over the brain and exchanges the local fluid among blood, intestinal fluid, and CSF. Observations using cellular and molecular biology as well as neuroimaging show that CSF physiology is more complicated than it is traditionally assumed. ![]() This literature reviews major developments that lead to the previous theories. et al., (2014) studied CSF physiology and revealed that CSF is secreted by epithelial cells of the choroid plexus and it flows via the ventricles, then flows in the middle of the subarachnoid space. Strict management of the CSF composition is essential and any difference can support in diagnosis (Sakka, L. Aging and various neurodegenerative diseases result due to the addition of metabolites because of a decrease in CSF turnover. In an average young person, this constant secretion helps in the detailed renewal of CSF four to five times daily. Choroid plexus secretes CSF, in adults this secretin ranges from 400 ml to 600 ml daily. The volume of CSF in adults is 150 ml around 25 ml is distributed within the ventricles and 125 ml within the subarachnoid spaces. The second mechanism reduces the effective brain weight that makes the brain and the spinal cord buoyant. CSF is ultra-filtrate of plasma that lies within the brain ventricles and the subarachnoid spaces of the cranium and spine (Sakka, L. In the first mechanism, it acts as a shock absorber that shields the brain against the skull (Telano, L. It gives hydro-mechanical protection of the neuraxis through two mechanisms. It performs main functions as if it protects and nourishes the brain and removes the wastage as well (Spector, R. It also helps in waste removal from the brain so that the nervous system will function normally. It acts as a shield and pillow to protect the brain and spinal cord from unexpected injuries. The brain and spinal cord form the central nervous system, which controls, and coordinates the working of all the body parts such as complex thinking and planning, muscle movement, and all organs functions. The ventricles that surround the brain and the spinal cord are filled with a clear, colourless, and ultra-filtrate of plasma that is known as cerebrospinal fluid. R1: What is the common symptom of CSF Fluid leak in the brain and Brain Tumor? This chapter examines various related researches to explain the background of brain cancer, CSF and multiple approach algorithm details to use in segmentation method of MRI and research questions that are mentioned in details. The motive of this chapter is to evaluate and use a proper scientific method to spot the research problems in a systematic and organized body of knowledge.
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